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163222-33-1 Information › Ezetimibe Analogues

163222-33-1 | Ezetimibe - Manufacturing for You

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Trademark:
Chemsigma
Product ID:
CS33442
CAS No:
163222-33-1
Product Name:
Ezetimibe
Molecular Formula:
C24H21F2NO3
Synonyms:
1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one
Usage:
Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.
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