Itraconazole [ 84625-61-6 ]

Cas Number: 84625-61-6
Product Code
103998
Product Name
Itraconazole
Cas Number
84625-61-6
Molecular Formula
C35H38Cl2N8O4
Appearance
off-white crystalline solid
Boiling Point
166 ( ℃ )

Purity: 98.0%, from toluene, melting point in 166.2 ℃ crystallization. PKa3.7. A few insoluble in water and dilute acid solution. Acute toxicity LD50 (14 days) mice, rats, dogs (mg/kg) : > > > 320, 320, 200 oral. Three thiazole ring of cysticercus cellulosae treated antifungal drugs. By preventing cytochromes P - 450 including enzymes and peroxidase activation, make 14, alpha methyl sterol cannot dehydrogenation and cannot be converted to MaiJiao sterol, thus make the fungus growth proliferation is restrained, have strong lipophilic character, but through biological membrane, inhibit the combination of membrane and fungi. Their antimicrobial spectrum and ketone health thiazole similar. To shallow sex fungus disease such as vaginal and oral candidiasis, skin MeiJunBing as more effective, and is expected to become a deep fungal infections disease such as cryptococcal meningitis (AIDS) of high efficinency safe drug. Used for sensitive caused by fungus's vulvae vaginal moniliosis, dalmatian KangZhen and skin fungus.

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