Ezetimibe

CAS163222-33-1

Ezetimibe (CAS 163222-33-1, C24H21F2NO3) is supplied by ChemSigma for research and manufacturing, with specification, analytical methods and batch documentation available on request.

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Chemical structure of Ezetimibe
C24H21F2NO3 · 409.43 g/mol
CAS No.
163222-33-1
Formula
C24H21F2NO3
Mol. weight
409.43 g/mol
Appearance
Solid

Chemical Specifications

Identifiers

CAS number 163222-33-1
Product name Ezetimibe
Synonyms 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one
Molecular formula C24H21F2NO3
Molecular weight 409.43 g/mol

Physical and chemical properties

Appearance Solid
Melting Point 162-164 ( ℃ )
Boiling Point 349.9 ( ℃ )
Specific Rotation -33, c = 1 in methanol ( ° )

Applications

Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.

Packaging, Storage & Transport

Available pack sizes 5kg, 1kg, 500g, 100g, 50g, 10g

Read the current safety data sheet before handling. Packaging can be adapted to the order quantity and destination.

Frequently Asked Questions

What is the CAS number of Ezetimibe?

The CAS Registry Number of Ezetimibe is 163222-33-1. Ezetimibe is also known as 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one.

What is the molecular formula and molecular weight of Ezetimibe?

The molecular formula of Ezetimibe is C24H21F2NO3, and its molecular weight is 409.43 g/mol.

What is Ezetimibe used for?

Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.

How can I request a quotation for Ezetimibe?

Send an inquiry for Ezetimibe (CAS 163222-33-1) with the required quantity, target specification, destination country and any documentation requirements. ChemSigma will confirm availability, packaging, lead time and price.

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