Ezetimibe
CAS163222-33-1
Ezetimibe (CAS 163222-33-1, C24H21F2NO3) is supplied by ChemSigma for research and manufacturing, with specification, analytical methods and batch documentation available on request.
- CAS No.
- 163222-33-1
- Formula
- C24H21F2NO3
- Mol. weight
- 409.43 g/mol
- Appearance
- Solid
Chemical Specifications
Identifiers
| CAS number | 163222-33-1 |
|---|---|
| Product name | Ezetimibe |
| Chinese name | 依折麦布 依泽替米贝 |
| Synonyms | 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one |
| Chinese synonyms | 1-(4-氟苯基)-(3R)-[3-(4-氟苯基)-(3S)-羟基丙基]-(4S)-(4-羟基苯基)-2-丙内酰胺; 依替米贝; 依泽替米贝; 伊折麦布; 一泽替米贝; 依折麦布; 依替米贝EZETIMIBE(研发中); 1-(4-氟苯基)-3(R)-[3-(4-氟苯基)-3(S)-羟丙基]-4(S)-(4-羟苯基)-2-吖丁啶(氮杂环丁烷)酮 |
| Molecular formula | C24H21F2NO3 |
| Molecular weight | 409.43 g/mol |
Physical and chemical properties
| Appearance | Solid |
|---|---|
| Melting Point | 162-164 ( ℃ ) |
| Boiling Point | 349.9 ( ℃ ) |
| Specific Rotation | -33, c = 1 in methanol ( ° ) |
Applications
Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.
Packaging, Storage & Transport
| Available pack sizes | 5kg, 1kg, 500g, 100g, 50g, 10g |
|---|
Read the current safety data sheet before handling. Packaging can be adapted to the order quantity and destination.
Frequently Asked Questions
What is the CAS number of Ezetimibe?
The CAS Registry Number of Ezetimibe is 163222-33-1. Ezetimibe is also known as 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one.
What is the molecular formula and molecular weight of Ezetimibe?
The molecular formula of Ezetimibe is C24H21F2NO3, and its molecular weight is 409.43 g/mol.
What is Ezetimibe used for?
Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.
How can I request a quotation for Ezetimibe?
Send an inquiry for Ezetimibe (CAS 163222-33-1) with the required quantity, target specification, destination country and any documentation requirements. ChemSigma will confirm availability, packaging, lead time and price.
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